Episode 1 of Rune's Pharmacy: Tiarajima no Okusuriya-san introduces young Erunelle, who inherits her parents' debts after their death. She is saved from a sexual assault by an orc by a man named Sharvan, who then reveals a document proving her parents' debt to him. He pressures her to sell her body to pay off the one million gold. This episode likely features the initial sexual encounters as Erunelle struggles to repay the debt.